"Assessment of retinal vessels is fundamental for the diagnosis of many disorders such as heart diseases, diabetes and hypertension. The imaging of retina using advanced fundus camera has become a standard in computer-assisted diagnosis of opthalmic disorders. Modern cameras produce high quality color digital images, but during the acquisition process the light reflected by the retinal surface generates a luminosity and contrast variation.

During a human brain MRI acquisition the resulting image is formed out of 2D slices. The slices must then be aligned and reconstructed to provide a 3-dimensional (3D) visualization of the brain volume. We propose in this work, an integrated system for the register ion and 3D reconstruction of DICOM MRI images and lesions of the brain acquired from multiple sclerosis (MS) subjects at two different time intervals (time 0 (T0) and time 1 (T1)). The system facilitates the follow up of the MS disease development and will aid the doctor to accurately manage the follow up of the disease.